Same-Day & Rush Delivery
Point-to-point across the Upstate and statewide. One call and a driver is rolling, measured in minutes, not next business day.
Dispatch open nowGreenville & all of South Carolina
Same-day delivery,
across South Carolina today.
When a package, specimen or document has to be there now, Professional Express Couriers drives it straight from pickup to drop-off. No terminals, no sorting hubs, no next-business-day. One call to Greenville dispatch and a driver is rolling.
Rush & STAT runs Insured, contracted drivers Early, late & weekends
Same-Day
Standard turnaround, statewide
1–10,000 lb
Cars, vans & 26-ft box trucks
7 Days
Dispatch reachable early, late & weekends
Insured
Contracted, professional drivers
Who we are
What does a contract courier in Greenville actually do for you?
Professional Express Couriers is a dedicated same-day delivery company based at 100 Tower Drive in Greenville, South Carolina. Manufacturers, labs, banks and offices across the Upstate hand us the deliveries they can't afford to get wrong: the STAT specimen, the missing part on a down line, the closing documents due by five.
We run cars, vans and 26-foot box trucks, so one phone number covers everything from a single envelope to a 10,000-pound freight load. You get a real dispatcher who knows your account and a price quoted up front, before we roll.
What we deliver
One courier for every time-critical delivery
Whatever has to move, and however fast it has to get there, there's a service and a vehicle built for it.
Medical, Lab & Hospital Courier
STAT specimen runs, lab-to-lab transport, pharmacy and hospital deliveries handled with careful, compliant chain-of-custody.
Bank & Financial Courier
Scheduled and on-demand runs for deposits, documents and inter-branch transfers. Dependable, discreet, on time.
Inter-Office & Route Delivery
Recurring routes that keep your locations in sync: mail, files and supplies moving between offices on a schedule you set.
Critical & Emergency Shipments
Down machine, missing part, deadline on the line? We treat critical freight as critical: direct, dedicated, tracked.
Postal Mail & Document Runs
Daily post office pickups and drop-offs, contracts and time-sensitive paperwork delivered signature-ready.
Package & Parcel Delivery
Single parcels to pallet loads. If it fits in a car, van or box truck, we move it, from 1 pound to 10,000.
Box-Truck & LTL Freight
26-foot box trucks with lift gates for pallets, displays and oversized loads that are too big for a parcel service.
How it works
How does a same-day run actually work?
From your call to a confirmed delivery, here's the whole process. Most local rush jobs are on the road within minutes.
01
Call or text dispatch
Reach a real person at (864) 444-9771. Tell us the pickup, the drop-off and how fast you need it.
02
We quote & assign in minutes
You get a clear price up front and the right vehicle (car, van or box truck) matched to your load.
03
Direct, dedicated transport
Your delivery goes straight from A to B. No terminals, no sorting hubs, no waiting on the next truck.
04
Confirmed delivery
We confirm the drop-off so you can close the loop with your customer, patient or branch with confidence.
Why businesses switch to us
Why choose a local courier over FedEx or UPS?
National carriers move your shipment through terminals and sorting hubs on their schedule. We drive it directly, on yours.
Direct, not hub-and-spoke
Your delivery goes straight from A to B in one vehicle. No terminals, no handoffs, no waiting on the next truck out.
Same-day is the standard
Rush and STAT runs aren't a premium add-on here. They're what we do all day, measured in minutes and hours.
A real dispatcher, not an app
Call and a person answers who knows your account, quotes you on the spot, and owns the delivery start to finish.
Insured & accountable
Professional, vetted contract drivers handle sensitive medical, bank and legal freight with real chain-of-custody.
One carrier, 1 to 10,000 lb
Envelopes to pallets. Cars, vans and lift-gate box trucks under one number, so you never juggle a second carrier.
After-hours & weekends
Emergencies don't keep business hours. Reach dispatch early, late and on weekends for critical shipments.
Coverage
Where in South Carolina do you deliver?
We're based in Greenville and run the whole state. Same-day across the Upstate is our backyard, and statewide runs to the Midlands, Columbia, the Lowcountry and Charleston are routine. If it's in South Carolina, we can get it there today.
Greenville Spartanburg Anderson Greer Easley Simpsonville Columbia Charleston Rock Hill Clemson+ all of SC
Industries we run for every day:
Manufacturing & DistributionMedical & Diagnostic LabsBanks & Credit UnionsLaw & Title OfficesPharmacies & HospitalsPrinters & PackagingAuto & Industrial PartsRetail & E-commerce
Statewide network
Greenville HQ Delivery points
Need a pickup outside the Upstate? We schedule statewide and long-distance runs daily. Call (864) 444-9771 and we'll build the route.
In their words
Trusted week in and week out
A top-tier carrier when it comes to reliability, pricing, and quality. They're a partner we count on week in and week out.
Kyle Brookshire
Logistics Manager, TK Supplies & Packaging
Professional Express has been an integral part of our business model for many years. Dependable every single time.
John Hooper
Del-Tec Packaging
Questions & answers
The questions dispatch hears every day
Straight answers about same-day courier service in Greenville and across South Carolina. Still stuck? Call or text (864) 444-9771.
How fast can I get a same-day courier in Greenville, SC?+
For most pickups in Greenville, Spartanburg and the surrounding Upstate we can have a driver on the way within minutes of your call. Same-day and rush deliveries are our standard service. You tell us the deadline and we build the run to hit it. Call or text dispatch at (864) 444-9771 for an on-the-spot time and price.
What areas of South Carolina do you cover?+
We're based at 100 Tower Drive in Greenville and deliver across all of South Carolina: the Upstate (Greenville, Spartanburg, Anderson, Greer, Easley), the Midlands and Columbia, the Lowcountry and Charleston, and everywhere in between. If it's in South Carolina, we can get it there today.
Do you offer medical and lab specimen delivery?+
Yes. Medical, lab and hospital courier work is one of our core services. We handle STAT specimen runs, lab-to-lab transport, pharmacy deliveries and hospital drop-offs with careful handling and dependable chain-of-custody. Recurring daily lab routes are available alongside on-demand STAT calls.
How much does a courier delivery cost?+
Pricing depends on the distance, the size of the load and how fast you need it. Because we quote every job up front, there are no surprises. You'll know the price before we roll. A short local rush costs far less than most people expect, and scheduled or recurring routes are discounted. Call or text (864) 444-9771 for a free quote in minutes.
What size loads can you carry?+
Everything from a single envelope to a 10,000-pound freight load. Our fleet includes cars and vans for documents and parcels, plus 26-foot box trucks with lift gates for pallets, displays and oversized freight. One company handles the whole range, so you don't need a second carrier when the load gets big.
Can you set up a scheduled or recurring delivery route?+
Absolutely. Many of our customers run daily or weekly routes with us: inter-office mail, bank runs, lab pickups, parts distribution. We build a standing schedule around your operation so the same reliable service shows up at the same time, without you having to call each day.
Is Professional Express Couriers insured?+
Yes. We're a professional contract courier company with insured, vetted drivers. Your shipment is handled by people who do this for a living, not a gig app, which is exactly why manufacturers, labs and banks across South Carolina trust us with time-critical and sensitive deliveries.
How do I schedule a delivery or get a quote?+
The fastest way is to call or text dispatch at (864) 444-9771. A real person answers and you get a price on the spot. You can also email dispatch@procarolinaexpress.com or use the quote form on this page. We monitor dispatch early, late and on weekends for urgent and after-hours runs.
What makes you different from FedEx, UPS or a national carrier?+
National carriers move your package through terminals and sorting hubs on their schedule. We drive it directly from pickup to drop-off on yours: no hubs, no handoffs, no waiting for the next truck. You get a dedicated driver, a real dispatcher who knows your account, and same-day speed a hub-and-spoke network can't match for local and statewide work.
Do you offer after-hours or emergency courier service?+
Yes. Emergency and critical shipments are a specialty. When a line goes down, a part is missing or a document has to be somewhere now, we treat it as the priority it is. Reach dispatch at (864) 444-9771 any time, including nights and weekends, for emergency dispatch.
Schedule your delivery
Get a free quote in minutes
No forms, no waiting. Call or text dispatch and a real person answers, quotes you on the spot, and gets a driver moving. Prefer email? Send us the details and we'll come right back with a price.
100 Tower Drive, Greenville, SC 29607Reachable early, late & weekends